Discovery of a 66 mas Ultracool Binary with Laser Guide Star Adaptive Optics

We present the discovery of 2MASS J21321145+1341584AB as a closely separated (0.066") very low-mass field dwarf binary resolved in the near-infrared by the Keck II Telescope using laser guide star adaptive optics. Physical association is deduced from the angular proximity of the components and constraints on their common proper motion. We have obtained a near-infrared spectrum of the binary and find that it is best described by an L5+/-0.5 primary and an L7.5+/-0.5 secondary. Model-dependent masses predict that the two components straddle the hydrogen burning limit threshold with the primary likely stellar and the secondary likely substellar. The properties of this sytem - close projected separation (1.8+/-0.3 AU) and near unity mass ratio - are consistent with previous results for very low-mass field binaries. The relatively short estimated orbital period of this system (~7-12 yr) makes it a good target for dynamical mass measurements. Interestingly, the system's angular separation is the tightest yet for any very low-mass binary published from a ground-based telescope and is the tightest binary discovered with laser guide star adaptive optics to date.Comment: 10 pages, 3 figures; accepted for publication to A

Potential effects of atmospheric collapse on Martian heat flow and application to the InSight measurements

Heat flow is an important constraint on planetary formation and evolution. It has been suggested that Martian obliquity cycles might cause periodic collapses in atmospheric pressure, leading to corresponding decreases in regolith thermal conductivity (which is controlled by gas in the pore spaces). Geothermal heat would then build up in the subsurface, potentially affecting present–day heat flow — and thus the measurements made by a heat–flow probe such as the InSight HP3 instrument. To gauge the order of magnitude of this effect, we model the diffusion of a putative heat pulse caused by thermal conductivity changes with a simple numerical scheme and compare it to the heat–flow perturbations caused by other effects. We find that an atmospheric collapse to 300 Pa in the last 40 kyr would lead to a present–day heat flow that is up to larger than the average geothermal background. Considering the InSight mission with expected error bars on the HP3 measurement, this perturbation would only be significant in the best-case scenario of full instrument deployment, completed measurement campaign, and a well–modelled surface configuration. The prospects for detecting long-term climate perturbations via spacecraft heat–flow experiments remain challenging

Further evidence for increased macrophage migration inhibitory factor expression in prostate cancer

BACKGROUND: Macrophage migration inhibitory factor (MIF) is a cytokine associated with prostate cancer, based on histologic evidence and circulating (serum) levels. Recent studies from another laboratory failed to document these results. This study's aims were to extend and confirm our previous data, as well as to define possible mechanisms for the discrepant results. Additional aims were to examine MIF expression, as well as the location of MIF's receptor, CD74, in human prostatic adenocarcinoma compared to matched benign prostate. METHODS: MIF amounts were determined in random serum samples remaining following routine PSA screening by ELISA. Native, denaturing and reducing polyacrylamide gels and Western blot analyses determined the MIF form in serum. Prostate tissue arrays were processed for MIF in situ hybridization and immunohistochemistry for MIF and CD74. MIF released into culture medium from normal epithelial, LNCaP and PC-3 cells was detected by Western blot analysis. RESULTS: Median serum MIF amounts were significantly elevated in prostate cancer patients (5.87 ± 3.91 ng/ml; ± interquartile range; n = 115) compared with patients with no documented diagnosis of prostate cancer (2.19 ± 2.65 ng/ml; n = 158). ELISA diluent reagents that included bovine serum albumin (BSA) significantly reduced MIF serum detection (p < 0.01). MIF mRNA was localized to prostatic epithelium in all samples, but cancer showed statistically greater MIF expression. MIF and its receptor (CD74) were localized to prostatic epithelium. Increased secreted MIF was detected in culture medium from prostate cancer cell lines (LNCaP and PC-3). CONCLUSION: Increased serum MIF was associated with prostate cancer. Diluent reagents that included BSA resulted in MIF serum immunoassay interference. In addition, significant amounts of complexed MIF (180 kDa under denaturing conditions by Western blot) found in the serum do not bind to the MIF capture antibody. Increased MIF mRNA expression was observed in prostatic adenocarcinoma compared to benign tissue from matched samples, supporting our earlier finding of increased MIF gene expression in prostate cancer

Discovery of a 0.15" Binary Brown Dwarf 2MASSJ 1426316+155701 With Gemini/Hokupa'a Adaptive Optics

Use of the highly sensitive Hokupa'a curvature wavefront sensor has allowed for the first time direct adaptive optics (AO) guiding on brown dwarfs and VLM stars (SpT=M7-L2). An initial survey of 9 such objects discovered one 0.15" binary (2MASSJ 1426316+155701). The companion is about half as bright as the primary (Delta K = 0.61+/-0.05$, Delta H = 0.70+/-0.05) and has even redder colors H-K=0.59+/-0.14 than the primary. The blended spectrum of the binary has been previously determined to be M9.0. We modeled a blend of an M8.5 template and a L1-L3 template reproducing a M9.0 spectrum in the case of Delta K = 0.61+/-0.05,Delta H = 0.70\pm0.05$. These spectral types also match the observed H-K colors of each star. Based the previously observed low space motion and $H_{\alpha}$ activity we assign an age of $0.8^{+6.7}_{-0.3} Gyr$. Utilizing this age range and the latest DUSTY models of the Lyon group we assign a photometric distance of $18.8^{+1.44}_{-1.02} pc$ and masses of $M_{A}=0.074^{+0.005}_{-0.011} M_\odot$ and $M_{B}=0.066^{+0.006}_{-0.015} M_\odot$. We therefore estimate a system separation of $2.92_{+0.22}^{-0.16}AU$ and a period of $13.3{+3.18}^{-1.51} yr$ respectively. Hence, 2M1426 is among the smallest separation brown dwarf binaries resolved to date

An analysis of technology gaps and priorities in support of probe-scale coronagraph and starshade missions

This paper provides a survey of the state-of-the-art in coronagraph and starshade technologies and highlights areas where advances are needed to enable future NASA exoplanet missions. An analysis is provided of the remaining technology gaps and the relative priorities of technology investments leading to a mission that could follow JWST. This work is being conducted in support of NASAs Astrophysics Division and the NASA Exoplanet Exploration Program (ExEP), who are in the process of assessing options for future missions. ExEP has funded Science and Technology Definition Teams to study coronagraphs and starshade mission concepts having a lifecycle cost cap of less than $1B. This paper provides a technology gap analysis for these concepts

The High-Order-Multiplicity of Unusually Wide M-dwarf Binaries: Eleven New Triple and Quadruple Systems

M-dwarfs in extremely wide binary systems are very rare, and may thus have different formation processes from those found as single stars or close binaries in the field. In this paper we search for close companions to a new sample of 36 extremely wide M-dwarf binaries, covering a spectral type range of M1 to M5 and a separation range of 600 - 6500 AU. We discover 10 new triple systems and one new quadruple system. We carefully account for selection effects including proper motion, magnitude limits, the detection of close binaries in the SDSS, and other sample biases. The bias-corrected total high-order-multiple fraction is 45% (+18%/-16%) and the bias-corrected incidence of quadruple systems is < 5%, both statistically compatible with that found for the more common close M-dwarf multiple systems. Almost all the detected companions have similar masses to their primaries, although two very low mass companions, including a candidate brown dwarf, are found at relatively large separations. We find that the close-binary separation distribution is strongly peaked towards < 30AU separations. There is marginally significant evidence for a change in high-order M-dwarf multiplicity with binding energy and total mass. We also find 2-sigma evidence of an unexpected increased high-order-multiple fraction for the widest targets in our survey, with a high-order-multiple fraction of 21% (+17%/-7%) for systems with separations up to 2000AU, compared to 77% (+9%/-22%) for systems with separations > 4000AU. These results suggest that the very widest M-dwarf binary systems need higher masses to form or to survive.Comment: 11 pages, 14 figures, accepted for publication in Ap

Lunar Seismometer and Burial System

Beginning in 1969, Apollo successfully deployed a long-lived network of seismometers on the Moon. Seismic studies provide definitive knowledge of internal planetary structure, and analysis of the Apollo seismic data has contributed to the magma ocean hypothesis for initial terrestrial planetary differentiation [Wieczoreket al., 2006]. While the general model is widely accepted, details such as mantle composition, stratification and possible overturn, lateral structure, and thermal inhomogeneities remain unresolved. The Moon experiences moonquakes at varying depths [Nakamura, 1983]. Shallow quakes are relatively large but rare, similar to terrestrial intra-plate earthquakes. Deeper quakes are comparatively smaller but more frequent, occurring periodically according to the tidal cycle. On the Moon, the lack of an atmosphere enables seismic experiments to potentially constrain meteorite impact flux, which informs cratering rates assumed throughout the solar system. The large diurnal temperature variation between day and night also induces thermal moonquakes, which may contribute to regolith production [Duennebier& Sutton, 1974; Weber et al., 2017]. Still, many questions remain regarding the frequency and distribution of natural moonquakes. This translates into an incomplete understanding of the Moons hemispherical dichotomies in crustal thickness, mare volcanism, seismicity, and the distribution of heat-producing elements. The Planetary Decadal Survey (National Research Council, 2013) identifies a New Frontiers Lunar Geophysical Network (LGN) mission to answer such questions

Macrophage Migration Inhibitory Factor Mediates PAR-Induced Bladder Pain.

INTRODUCTION: Macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine, is constitutively expressed in urothelial cells that also express protease-activated receptors (PAR). Urothelial PAR1 receptors were shown to mediate bladder inflammation. We showed that PAR1 and PAR4 activator, thrombin, also mediates urothelial MIF release. We hypothesized that stimulation of urothelial PAR1 or PAR4 receptors elicits release of urothelial MIF that acts on MIF receptors in the urothelium to mediate bladder inflammation and pain. Thus, we examined the effect of activation of specific bladder PAR receptors on MIF release, bladder pain, micturition and histological changes. METHODS: MIF release was measured in vitro after exposing immortalized human urothelial cells (UROtsa) to PAR1 or PAR4 activating peptides (AP). Female C57BL/6 mice received intravesical PAR1- or PAR4-AP for one hour to determine: 1) bladder MIF release in vivo within one hour; 2) abdominal hypersensitivity (allodynia) to von Frey filament stimulation 24 hours after treatment; 3) micturition parameters 24 hours after treatment; 4) histological changes in the bladder as a result of treatment; 5) changes in expression of bladder MIF and MIF receptors using real-time RT-PCR; 6) changes in urothelial MIF and MIF receptor, CXCR4, protein levels using quantitative immunofluorescence; 7) effect of MIF or CXCR4 antagonism. RESULTS: PAR1- or PAR4-AP triggered MIF release from both human urothelial cells in vitro and mouse urothelium in vivo. Twenty-four hours after intravesical PAR1- or PAR4-AP, we observed abdominal hypersensitivity in mice without changes in micturition or bladder histology. PAR4-AP was more effective and also increased expression of bladder MIF and urothelium MIF receptor, CXCR4. Bladder CXCR4 localized to the urothelium. Antagonizing MIF with ISO-1 eliminated PAR4- and reduced PAR1-induced hypersensitivity, while antagonizing CXCR4 with AMD3100 only partially prevented PAR4-induced hypersensitivity. CONCLUSIONS: Bladder PAR activation elicits urothelial MIF release and urothelial MIF receptor signaling at least partly through CXCR4 to result in abdominal hypersensitivity without overt bladder inflammation. PAR-induced bladder pain may represent an interesting pre-clinical model of Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS) where pain occurs without apparent bladder injury or pathology. MIF is potentially a novel therapeutic target for bladder pain in IC/PBS patients

Thrombin Induces Macrophage Migration Inhibitory Factor Release and Upregulation in Urothelium: A Possible Contribution to Bladder Inflammation

Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine expressed by urothelial cells that mediates bladder inflammation. We investigated the effect of stimulation with thrombin, a Protease Activated Receptor-1 (PAR1) agonist, on MIF release and MIF mRNA upregulation in urothelial cells.MIF and PAR1 expression was examined in normal human immortalized urothelial cells (UROtsa) using real-time RT-PCR, Western blotting and dual immunostaining. MIF and PAR1 immunostaining was also examined in rat urothelium. The effect of thrombin stimulation (100 nM) on urothelial MIF release was examined in UROtsa cells (in vitro) and in rats (in vivo). UROtsa cells were stimulated with thrombin, culture media were collected at different time points and MIF amounts were determined by ELISA. Pentobarbital anesthetized rats received intravesical saline (control), thrombin, or thrombin +2% lidocaine (to block nerve activity) for 1 hr, intraluminal fluid was collected and MIF amounts determined by ELISA. Bladder or UROtsa MIF mRNA was measured using real time RT-PCR.UROtsa cells constitutively express MIF and PAR1 and immunostaining for both was observed in these cells and in the basal and intermediate layers of rat urothelium. Thrombin stimulation of urothelial cells resulted in a concentration- and time-dependent increase in MIF release both in vitro (UROtsa; 2.8-fold increase at 1 hr) and in vivo (rat; 4.5-fold) while heat-inactivated thrombin had no effect. In rats, thrombin-induced MIF release was reduced but not abolished by intravesical lidocaine treatment. Thrombin also upregulated MIF mRNA in UROtsa cells (3.3-fold increase) and in the rat bladder (2-fold increase) where the effect was reduced (1.4-fold) by lidocaine treatment.Urothelial cells express both MIF and PAR1. Activation of urothelial PAR1 receptors, either by locally generated thrombin or proteases present in the urine, may mediate bladder inflammation by inducing urothelial MIF release and upregulating urothelial MIF expression